Missed doses can lead to treatment failure, relapse, and acquired drug resistance.ħ days/week for 14 doses then twice weekly for 12 doses gĭo not use twice-weekly regimens in HIV-infected patients or patients with smear positive and/or cavitary disease. Use regimen with caution in patients with HIV and/or cavitary disease. Preferred alternative regimen in situations in which more frequent DOT during continuation phase is difficult to achieve. ĭPyridoxine (vitamin B6), 25–50 mg/day, should be given with isoniazid to all patients.ĮDrugs are administered with food once a day, every day of the week.ĬDC developed a checklist resource for healthcare providers and TB programs to ensure the correct timing of testing and monitoring for patients through the 4-month rifapentine-moxifloxacin regimen.
If this target is not met, the patient should be considered to have interrupted therapy and should be managed as described in TB treatment guidelines.
Contact your state or local TB control office for more information about eDOT policies and procedures.ĬMust be administered within 84 days from intensive phase completion. Where local policies, allow, eDOT has been shown to be an acceptable alternative to traditional DOT. The healthcare worker should ask the patient how he or she is feeling, check the medications before they are taken, ask the patient if he or she is experiencing any side effects, and answer any questions the patient may have. Directly observed therapy means that a healthcare worker watches the TB patient swallow each dose of the prescribed drugs. īAt least 5 of 7 weekly doses should be administered under direct observation. The 4-month rifapentine-moxifloxacin TB treatment regimen is as effective as (noninferior to) the standard daily 6-month regimen in curing drug-susceptible TB disease.Ībbreviations: RPT= rifapentine MOX= Moxifloxacin INH = isoniazid PZA = pyrazinamideĪMust be administered completely within 70 days from treatment initiation. Recommended for people ages 12 and older with body weight at or above 40 kg, with pulmonary TB caused by organisms that are not known or suspected to be drug-resistant, and who have no contraindications to this regimen. 4-month rifapentine-moxifloxacin TB treatment regimen Intensive Phase Highlights from the 2016 Treatment of Drug-Susceptible Tuberculosis Guidelines.Note: this table is an excerpt from Treatment of Drug-Susceptible Tuberculosis and cites supporting information available in the complete guidelines. Doses of Antituberculosis Drugs for Adults and Children Treatment of Drug-Susceptible Tuberculosis.6- or 9-month RIPE TB Treatment Regimen.Considerations for Specific People with TB Disease.Frequently Asked Questions (FAQs) on a 4-month rifapentine-moxifloxacin TB treatment regimen.Interim Guidance: 4-Month Rifapentine-Moxifloxacin Regimen for the Treatment of Drug-Susceptible Pulmonary Tuberculosis - United States, 2022.New4-month Rifapentine-moxifloxacin TB Treatment Regimen.TB treatment can take 4, 6, or 9 months depending on the regimen. There are several treatment regimens recommended in the United States for TB disease. Evaluation and Testing Considerations for Drug-susceptible Pulmonary TB Treatment Regimens.Treatment Regimen Considerations for Specific Groups of People with TB Disease.
Drug-Susceptible TB Disease Treatment Regimens.The solution, shown on the right, should be easy but is very hard in practice. On the left are shown nine dots to be connected by four straight lines, without lifting the pen from the paper and without retracing any lines. It was first discussed by the US psychologist Norman R(aymond) F(rederick) Maier (1900–1977) in an article in the Journal of Comparative Psychology in 1930. It is often used to illustrate lateral thinking and is a perfect example of ‘thinking outside the box’. Fewer than 5 per cent of undergraduate students manage to solve it in two minutes, and most are convinced by then that no solution exists. If symmetric solutions are considered equivalent, then it is a well-defined problem, and it should be easy, because there are only a few possibilities to try, but it is difficult in practice for psychological reasons. A reasoning problem in which the task is to connect nine dots, arranged in a square, by four straight lines drawn without lifting the pen from the paper and without retracing any lines (see illustration).
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